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In published in-vitro pharmacology, the molecule shows full agonist activity at GLP-1R and GIPR with somewhat attenuated potency at GCGR, a profile designed to bias signaling toward energy expenditure while limiting hyperglycemic risk in preclinical assays (Coskun et al., 2022)
The scientists looked at the health records of more than 95,000 patients, including 22,480 people who used GLP-1s
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